Key Largo is the first island you will see as you enter the 110-mile Florida Keys chain.  It is the  longest island and the one where Humphrey Bogart and Lauren Bacall battled Edward G. Robinson and a hurricane in the 1948 gangster movie “Key Largo.”

Today, visitors can take a tour on The African Queen, the boat Bogart and Katharine Hepburn fell in love in the 1951 movie, “The African Queen,” which is set in World War I Africa.

After Key Largo you will reach Islamorada, a village of homey islands that includes Windley Key, Upper Matecumbe Key and Lower Matecumbe Key. Morada means purple in Spanish, and lore has it the early Spanish explorers named these isles for the floating purple sea snails, or janthina janthina, they probably saw feeding on jelly fish near the islands.

Islamorada also prides itself as the Sportfishing Capital of the World. Here, you can venture offshore on a charter boat for a chance at the beautiful, acrobatic sailfish or the magnificently colored dolphin fish, a.k.a mahi-mahi. Hire a guide and you can take to the shallow near-shore waters to catch the mysterious ghost of the flats, the bonefish, or venture into the backcountry to catch redfish and tarpon.

Next, you will reach Marathon, a small city at the mid-point of the Florida Keys. Nearby is Key Colony Beach, a beautiful village of quaint homes and marinas. If golf is your game, you’ve come to the right place. Both Marathon and Key Colony have excellent courses.

After Marathon, you will reach the foot of the Seven Mile Bridge which is the gateway to the Lower Keys. Don’t pass up the small island below the bridge. Pigeon Key once housed the workers who built Flaglers' railroad in the early 1900s. Today, you can take a tour of this island and view a snapshot of life in the early 20th century.

After the Seven Mile Bridge, the vast sweep of the Straits of Florida and the Gulf of Mexico can easily be seen from Bahia Honda Bridge. Stop at the state park here and you can experience a beach that is frequently listed as one of the most beautiful in the United States. It’s easy to see why the Keys are recognized as America's Caribbean Islands.

Big Pine Key and the rest of the Lower Keys are next. Big Pine is the jumping off point for Looe Key, a shallow coral formation that is one of the most spectacular shallow water dive locations anywhere. Big Pine is also home to the diminutive Key deer, a subspecies of the white tail deer. There are even a few alligators in a pond nicknamed the Blue Hole that’s tucked away in a pine and palm grove.

Keep exploring and before long, you will find yourself in Key West, the final stop on the Overseas Highway. Here, the land meets the sea amid 19th-century charm and 21st-century attractions. This is the nation's southernmost city, and it is actually closer to Havana than Miami.

Stop to chat with the locals and you might come across one of the native-born Key Westers, who call themselves Conchs. Be sure to ask the Conchs about the Key West of their childhood, from the tropical fruit trees in their yards to the namesake shellfish they gathered in the shallow near-shore waters.

If you’ve timed your drive right, you’ve reached Key West just in time for sunset. Visitors and local artists gather on the dock at Mallory Square each evening to celebrate the end to another tropical day. Musicians, jugglers, mimes, and the occasional fire-eater entertain you while local food vendors keep you fed. The daily sunset celebration has become one of Key West’s greatest traditions.

After sunset, the fun is just beginning. When the night falls, chances are you can find a restaurant or watering hole to meet your tastes. Many bars offer live music, including New Orleans-style jazz and local tropical creations. If you like plays or musicals, you’re in luck too. Key West has several small theaters that showcase performances by local acting troupes. And the island even has a symphony now.

When you lie down at the end of the day, you’ll realize the drive was worth it.